A cross-cancer differential co-expression network reveals microRNA-regulated oncogenic functional modules
نویسندگان
چکیده
منابع مشابه
Supporting Information Cross-cancer differential co-expression network reveals microRNA- regulated oncogenic functional modules
متن کامل
Module Network Inference from a Cancer Gene Expression Data Set Identifies MicroRNA Regulated Modules
BACKGROUND MicroRNAs (miRNAs) are small RNAs that recognize and regulate mRNA target genes. Multiple lines of evidence indicate that they are key regulators of numerous critical functions in development and disease, including cancer. However, defining the place and function of miRNAs in complex regulatory networks is not straightforward. Systems approaches, like the inference of a module networ...
متن کاملIdentification of cancer prognosis-associated functional modules using differential co-expression networks
The rapid accumulation of cancer-related data owing to high-throughput technologies has provided unprecedented choices to understand the progression of cancer and discover functional networks in multiple cancers. Establishment of co-expression networks will help us to discover the systemic properties of carcinogenesis features and regulatory mechanisms of multiple cancers. Here, we proposed a c...
متن کاملSingle-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes
Co-expression analysis has been employed to predict gene function, identify functional modules, and determine tumor subtypes. Previous co-expression analysis was mainly conducted at bulk tissue level. It is unclear whether co-expression analysis at the single-cell level will provide novel insights into transcriptional regulation. Here we developed a computational approach to compare glioblastom...
متن کاملDifferential Network Analysis Reveals Genetic Effects on Catalepsy Modules
We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing four inbred strains (HS4) and a heterogeneous stock (HS-CC) formed from the inbred strain founders of the Collaborative Cross (CC). All three selections were s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular BioSystems
سال: 2015
ISSN: 1742-206X,1742-2051
DOI: 10.1039/c5mb00443h